This city covers a total area of 7.13 square miles and is one of the most important locations in the state. Boston is the largest and capital city of Massachusetts State, 125 km 2 of area and population of 645,966 estimated of the year 2013, located in the Suffolk County. The city has a population of 111,670 making it the fifth-largest city in the state. The USA.com website and domain are privately owned and are not operated by or affiliated with … Contents: Cities, Towns & Places The population of all cities, towns and unincorporated places in Massachusetts with more than 15,000 inhabitants according … Asked in Massachusetts Which are the largest cities in Massachusetts? There, you will find American history as vibrant and living as in any city in the entire country. It has an estimated population of 110,000. Boston had a population of over 617,500 people in 2012. The largest city in Massachusetts is Boston. boston, springfield, are there any others. Located in Middlesex County, just north of Boston, Cambridge is the fifth largest city in Massachusetts. Please help improve this article by adding citations to reliable sources.Unsourced material may be challenged and removed. Some of the most incredible hotels and restaurants in the world are found in the capital city of Boston. Cambridge is the city with highest density of inhabitants at 6,482 per km 2 on the area of 16 km 2. Historically a manufacturing center and even claiming the largest industrial complex in the county circa 1850, Lowell is now more important for historic and cultural reasons rather than economic. Wiki User May 14, 2013 2:10PM. Largest Cities in Massachusetts? The next largest city is Worcester, Massachusetts with a population of about 181,000 people. Related Questions. This article needs additional citations for verification. Most / Least Educated Cities in CA Most / Least Educated States in U.S. On top of that, there are excellent attractions in Massachusetts, including Fenway Park, Cape Cod, and other small coastal towns. Information for Massachusetts state - population, growth, income, time zone, area codes on localistica.com October 2014) (Learn how and when to remove this template message)